MovDisordV3, France, Analysis, bibRecord, 000179

Apomorphine effect on pain threshold in Parkinson's disease: A clinical and positron emission tomography study

Identifieur interne : 000179 ( France/Analysis ); précédent : 000178; suivant : 000180

Apomorphine effect on pain threshold in Parkinson's disease: A clinical and positron emission tomography study

Auteurs : Estelle Dellapina [France] ; Angélique Gerdelat-Mas [France] ; Fabienne Ory-Magne [France] ; Laure Pourcel [France] ; Monique Galitzky [France] ; Fabienne Calvas [France] ; Marion Simonetta-Moreau [France] ; Claire Thalamas [France] ; Pierre Payoux [France] ; Christine Brefel-Courbon [France]

Source :

Movement Disorders [ 0885-3185 ] ; 2011-01.

RBID : ISTEX:0FE03C86D5A2B78BBBBBF3C8873095BA4F7F1891

Descripteurs français

Pascal (Inist)
- Apomorphine, Douleur, Maladie de Parkinson, Pathologie du système nerveux, Tomographie par émission de positons, Tomoscintigraphie.

English descriptors

KwdEn :
- Aged, Antiparkinson Agents (pharmacology), Antiparkinson Agents (therapeutic use), Apomorphine (pharmacology), Apomorphine (therapeutic use), Cerebral Cortex (radionuclide imaging), Double-Blind Method, Emission tomography, Female, Humans, H 215O positron emission tomography, Male, Middle Aged, Nervous system diseases, Neuralgia (diagnosis), Neuralgia (etiology), Oxygen Isotopes (diagnostic use), Pain, Pain Threshold (drug effects), Parkinson Disease (complications), Parkinson Disease (drug therapy), Parkinson Disease (pathology), Parkinson Disease (radionuclide imaging), Parkinson disease, Parkinson's disease, Positron emission tomography, Positron-Emission Tomography (methods), apomorphine, pain threshold.
MESH :
- chemical , diagnostic use : Oxygen Isotopes.
- chemical , pharmacology : Antiparkinson Agents, Apomorphine.
- chemical , therapeutic use : Antiparkinson Agents, Apomorphine.
- complications : Parkinson Disease.
- diagnosis : Neuralgia.
- drug effects : Pain Threshold.
- drug therapy : Parkinson Disease.
- etiology : Neuralgia.
- methods : Positron-Emission Tomography.
- pathology : Parkinson Disease.
- radionuclide imaging : Cerebral Cortex, Parkinson Disease.
- Aged, Double-Blind Method, Female, Humans, Male, Middle Aged.

Abstract

Patients with Parkinson's disease (PD) frequently experience pain that could be in part due to central modification of nociception. In this randomized controlled double blind study, we compared the effect of apomorphine versus placebo on pain thresholds and pain‐induced cerebral activity in 25 patients with PD. Subjective pain threshold (using thermal stimulation, thermotest), objective pain threshold (nociceptive flexion reflex), and cerebral activity (H 215O PET) during noxious and innocuous stimulations were performed. Neither subjective nor objective pain thresholds nor pain activation profile were modified by apomorphine compared with placebo in 25 PD patients. Apomorphine has no effect on pain processing in PD. We suggest that other monoamine systems than dopaminergic system could be involved. © 2010 Movement Disorder Society.

Url:

https://api.istex.fr/document/0FE03C86D5A2B78BBBBBF3C8873095BA4F7F1891/fulltext/pdf

DOI: 10.1002/mds.23406

Affiliations:

Links to Exploration step

ISTEX:0FE03C86D5A2B78BBBBBF3C8873095BA4F7F1891

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Antiparkinson Agents (pharmacology)</term>
<term>Antiparkinson Agents (therapeutic use)</term>
<term>Apomorphine (pharmacology)</term>
<term>Apomorphine (therapeutic use)</term>
<term>Cerebral Cortex (radionuclide imaging)</term>
<term>Double-Blind Method</term>
<term>Emission tomography</term>
<term>Female</term>
<term>Humans</term>
<term>H 215O positron emission tomography</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nervous system diseases</term>
<term>Neuralgia (diagnosis)</term>
<term>Neuralgia (etiology)</term>
<term>Oxygen Isotopes (diagnostic use)</term>
<term>Pain</term>
<term>Pain Threshold (drug effects)</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson Disease (radionuclide imaging)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Positron emission tomography</term>
<term>Positron-Emission Tomography (methods)</term>
<term>apomorphine</term>
<term>pain threshold</term>
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<term>Apomorphine</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Apomorphine</term>
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<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Neuralgia</term>
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Pain Threshold</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
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<term>Parkinson Disease</term>
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<term>Double-Blind Method</term>
<term>Female</term>
<term>Humans</term>
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<term>Middle Aged</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Apomorphine</term>
<term>Douleur</term>
<term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
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<front><div type="abstract" xml:lang="en">Patients with Parkinson's disease (PD) frequently experience pain that could be in part due to central modification of nociception. In this randomized controlled double blind study, we compared the effect of apomorphine versus placebo on pain thresholds and pain‐induced cerebral activity in 25 patients with PD. Subjective pain threshold (using thermal stimulation, thermotest), objective pain threshold (nociceptive flexion reflex), and cerebral activity (H 215O PET) during noxious and innocuous stimulations were performed. Neither subjective nor objective pain thresholds nor pain activation profile were modified by apomorphine compared with placebo in 25 PD patients. Apomorphine has no effect on pain processing in PD. We suggest that other monoamine systems than dopaminergic system could be involved. © 2010 Movement Disorder Society.</div>
</front>
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<tree><country name="France"><noRegion><name sortKey="Dellapina, Estelle" sort="Dellapina, Estelle" uniqKey="Dellapina E" first="Estelle" last="Dellapina">Estelle Dellapina</name>
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<name sortKey="Brefel Ourbon, Christine" sort="Brefel Ourbon, Christine" uniqKey="Brefel Ourbon C" first="Christine" last="Brefel-Courbon">Christine Brefel-Courbon</name>
<name sortKey="Brefel Ourbon, Christine" sort="Brefel Ourbon, Christine" uniqKey="Brefel Ourbon C" first="Christine" last="Brefel-Courbon">Christine Brefel-Courbon</name>
<name sortKey="Brefel Ourbon, Christine" sort="Brefel Ourbon, Christine" uniqKey="Brefel Ourbon C" first="Christine" last="Brefel-Courbon">Christine Brefel-Courbon</name>
<name sortKey="Brefel Ourbon, Christine" sort="Brefel Ourbon, Christine" uniqKey="Brefel Ourbon C" first="Christine" last="Brefel-Courbon">Christine Brefel-Courbon</name>
<name sortKey="Calvas, Fabienne" sort="Calvas, Fabienne" uniqKey="Calvas F" first="Fabienne" last="Calvas">Fabienne Calvas</name>
<name sortKey="Dellapina, Estelle" sort="Dellapina, Estelle" uniqKey="Dellapina E" first="Estelle" last="Dellapina">Estelle Dellapina</name>
<name sortKey="Galitzky, Monique" sort="Galitzky, Monique" uniqKey="Galitzky M" first="Monique" last="Galitzky">Monique Galitzky</name>
<name sortKey="Gerdelat As, Angelique" sort="Gerdelat As, Angelique" uniqKey="Gerdelat As A" first="Angélique" last="Gerdelat-Mas">Angélique Gerdelat-Mas</name>
<name sortKey="Ory Agne, Fabienne" sort="Ory Agne, Fabienne" uniqKey="Ory Agne F" first="Fabienne" last="Ory-Magne">Fabienne Ory-Magne</name>
<name sortKey="Payoux, Pierre" sort="Payoux, Pierre" uniqKey="Payoux P" first="Pierre" last="Payoux">Pierre Payoux</name>
<name sortKey="Payoux, Pierre" sort="Payoux, Pierre" uniqKey="Payoux P" first="Pierre" last="Payoux">Pierre Payoux</name>
<name sortKey="Pourcel, Laure" sort="Pourcel, Laure" uniqKey="Pourcel L" first="Laure" last="Pourcel">Laure Pourcel</name>
<name sortKey="Simonetta Oreau, Marion" sort="Simonetta Oreau, Marion" uniqKey="Simonetta Oreau M" first="Marion" last="Simonetta-Moreau">Marion Simonetta-Moreau</name>
<name sortKey="Simonetta Oreau, Marion" sort="Simonetta Oreau, Marion" uniqKey="Simonetta Oreau M" first="Marion" last="Simonetta-Moreau">Marion Simonetta-Moreau</name>
<name sortKey="Simonetta Oreau, Marion" sort="Simonetta Oreau, Marion" uniqKey="Simonetta Oreau M" first="Marion" last="Simonetta-Moreau">Marion Simonetta-Moreau</name>
<name sortKey="Thalamas, Claire" sort="Thalamas, Claire" uniqKey="Thalamas C" first="Claire" last="Thalamas">Claire Thalamas</name>
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Movement Disorders (revue)

Apomorphine effect on pain threshold in Parkinson's disease: A clinical and positron emission tomography study

Apomorphine effect on pain threshold in Parkinson's disease: A clinical and positron emission tomography study

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Descripteurs français

English descriptors

Abstract

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Links to Exploration step

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Pour manipuler ce document sous Unix (Dilib)

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	Movement Disorders (revue)
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